Newborn Screening Services

What is Newborn Metabolic Screening?

Newborn Metabolic Screening Services detect selected metabolic and genetic conditions at birth. All infants born in North Carolina are screened at birth for the following conditions:

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Critical Congenital Heart Defects (CCHD) Screening

In addition to newborn metabolic screening tests, the state of North Carolina recently passed legislation to screen every infant born in North Carolina for Critical Congenital Heart Defects. See the CCHD Screening and Reporting Letter for Providers. This screening test is a simple and painless way to identify some, but not all, infants born with heart defects who may not show other signs and symptoms. This screening is typically performed at hospitals.
- Critical Congenital Heart Defects Resources

General Information for Parents About CCHD

Information about CCHD Screening

Information for Hospitals and Providers

A Model Toolkit for Hospitals to Learn about the Nationally Recommended CCHD Screening Protocol and Process

  • Congenital hypothyroidism (CH)
  • Galactosemia
  • Congenital Adrenal Hyperplasia (CAH)
  • Hemoglobinopathy Disease (e.g., sickle cell)
  • Biotinidase Deficiency
  • Certain metabolic disorders detectable by "Tandem Mass Spectrometry" (TMS), including Phenylketonuria (PKU)

If a baby’s results for this screening are abnormal, the baby's doctor will be contacted by the Newborn Screening Program. The baby will be referred for more laboratory testing and, based on the results, may also be referred to a major medical center or Subspecialist office for treatment. Treatment centers include, but are not limited to:

  • Atrium Health Carolinas Medical Center, Charlotte
  • Duke University Medical Center, Durham
  • East Carolina University, Greenville
  • Mission Hospital, Asheville
  • University of North Carolina, Chapel Hill
  • Atrium Health Wake Forest Baptist Medical, Winston-Salem


For more information about this service contact:

  • Whole Child Health Section, 919-707-5600