NC Controlled Substances Reporting System

The NC Controlled Substances Reporting System (CSRS) collects information on dispensed controlled substance prescriptions and makes this information available to prescribers and dispensers. The system is used as a clinical tool to improve patient care and safety while avoiding potential drug interactions and identifying individuals that may be in need of referral to substance use disorder services. In addition, prescribers can audit their personal controlled substances prescribing history.
Controlled Substances Reporting System
Integration Resources
CSRS Mandatory Compliance and Technical Assistance
Legal Updates

Frequently Asked Questions

Tab/Accordion Items

  • CSRS Registration Instructions: All prescribers, pharmacists, and delegates may apply through the NC CSRS website at
  • Select  "Create an Account" and follow the provided instructions.

Yes.  Out-of-state providers can register with the system to query NC patients using the Out of State Prescriber role.

  • Call the dispensing pharmacy to verify the CSRS data. 
  • If the prescription is determined to be in error, ask the pharmacist to resubmit with the correct information. 
  • For further questions or concerns, email

A step-by-step guide for dispensers can be found here: Data Submission Dispenser Guide

Yes. Complete the Request for Individual's Own Controlled Substances Reporting System Information Form  and mail it, along with a copy of your photo ID, to the address below:

Controlled Substances Reporting System
Attn: Patient Profile Desk
Mail Service Center 3008
Raleigh, NC 27699-3008